Site with practically static content = use your CMS to "staticalize" the pages then upload them. You only have to do this if something updates or if you decide to change your layout. This is like, for old articles, or stuff. Less server overhead.Kind of how like blogger.com works when you use the FTP publish. Not the beta blogger, the "old" blogger. Site with usually changing content = mod_rewrite might be a good idea.
It depends though on what you want to achieve and how much computing power you have, and if .0001 seconds make a difference or not. I personally have little need for the dynamic stuff on my sites
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